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Rimonabant 20mg (Acomplia, Chantix, Riobant, Slimona, Rimoslim, Zimulti) is the first in a new class of therapeutic agents called Cannabinoid-1 Receptor Blockers (CB1).
Rimonabant 20mg is used in the treatment of obesity and related conditions.

Rimonabant 20mg acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1.
Rimonabant 20mg switches off the same brain circuits that make people hungry when they smoke cannabis.
CB1 receptor blockade with Rimonabant 20mg acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.

Rimonabant 20mg is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood.
Sanofi argues that Rimonabant 20mg can also prevent the risk of cardiovascular disease.
Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug.

Rimonabant 20mg has been studied by sanofi-aventis as an aid to smoking cessation based on studies for up to one year in over 6,500 smokers motivated to quit smoking.
Sanofi-aventis submitted a New Drug Application to the FDA, which in turn issued a non approvable letter for Rimonabant 20mg for use in smoking cessation. An approvable letter was however issued for Rimonabant 20mg for use in weight management.

No. Sanofi is still awaiting U.S. marketing go-ahead which it has said could come by the end of this year.
U.S. health authorities have asked Sanofi for more information on Rimonabant 20mg.
Rimonabant 20mg received European Union marketing approval in June 2006.
The first launch will take place in Britain in July and be followed by launches in Denmark, Ireland, Germany, Finland and Norway in the second half of this year, according to Sanofi.

In clinical studies, Rimonabant 20mg has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss4,5.
Approximately half of the observed improvement in HDL-cholesterol, triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Rimonabant 20mg was beyond that expected from weight loss alone.

Side effects in the trial on Rimonabant 20mg in obesity were vomiting and nausea, forcing about 19 percent of patients to leave the trial versus 13 percent of those who took placebo.

The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.